Table 6 Exposure estimates in females for Δ9-tetrahydrocannabinol (9-THC) and Cannabidiol (CBD) in beef fat from cattle administered industrial hemp inflorescence.

From: Tissue residue depletion of cannabinoids in cattle administered industrial hemp inflorescence

  

Cannabinoid intake3

Allowable exposure4

Intake/allowable5

Age

BW1

Fat intake2

9-THC

CBD

9-THC

CBD

9-THC

CBD

y

kg

g/d

ng/d

ng/d

µg

µg

%

%

Newborn

3.29

69

5,150

25,600

3.29

493

157

5.19

0.5

7.66

69

5,150

25,600

7.66

1,150

67.2

2.23

1

9.79

89

6,650

33,000

9.79

1,470

67.9

2.24

1.5

11.11

89

6,650

33,000

11.1

1,670

59.9

1.98

2–3

12.48

109

8,140

40,400

12.5

1,870

65.1

2.16

3–6

15.4

130

9,710

48,200

15.4

2,310

63.1

2.09

6–11

23.7

123

9,190

45,600

23.7

3,550

38.8

1.28

11–16

48.1

223

16,700

82,700

48.1

7,210

34.7

1.15

16–21

65.7

278

20,800

103,000

65.7

9,850

31.7

1.05

21–31

74.9

160

12,000

59,400

74.9

11,200

16.0

0.530

31–41

79.3

160

12,000

59,400

79.3

11,900

15.1

0.499

41–51

80.8

150

11,200

55,600

80.8

12,100

13.9

0.460

51–61

78.7

126

9,410

46,700

78.7

11,800

12.0

0.396

61–71

78.2

120

8,960

44,500

78.2

11,700

11.5

0.380

71–81

74.7

144

10,800

53,400

74.7

11,200

14.5

0.477

81+

67.9

137

10,200

50,800

67.9

10,200

15.0

0.498

  1. 1Body weight (BW) values represent means for each sex and age group and were retrieved from the Centers for Disease Control (CDC), with most values extracted from anthropometric data from 2015-2018 and values for newborn through 2 y extracted from the most recent growth charts (2000)36,37. Where ages did not align with the fat intake groups, the BW associated with the youngest age for the intake range was used. For ages 21+, the BW of the most similar age group to the fat intake age group was used (e.g. for the 31–41 y intake group, BW from 30–39 y was used). 2Fat intake data (95th percentiles within males and females) of each age group were retrieved from Tables 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37 and 38 of the 2018 Environmental Protection Agency Exposure Factors Handbook representing the top decile of animal fat consumers35. For age ranges 71–81 y and 81+ y, separate data were not available for males and females.
  2. 3Intake was calculated as (Fat intake in g/d) × (9-THC or CBD concentration in ng/g). Concentrations of 9-THC and CBD were the upper 99% CI from the day with the highest 9-THC or CBD concentrations in cattle adipose tissue (day 2): 74.7 ng/g and 371 ng/g, respectively. 4The allowable 9-THC exposure (1 µg/kg/d) is from the acute reference dose (ARfD) published by the European Food Safety Authority (EFSA)9. The allowable CBD exposure (0.15 mg/kg/d = 150 µg/kg/d) is from the acceptable daily intake (ADI) published by the Food Standards Agency (FSA).10 5Intake/allowable was calculated as [(ng intake of 9-THC) ÷ 1,000 ng/µg)] ÷ (µg allowable exposure of 9-THC) × 100% and [(ng intake of CBD) ÷ 1,000 ng/µg)] ÷ (µg allowable exposure of CBD) × 100%.
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