Fig. 2

The FGA, FGB, and FGG expression pattern and their clinical correlations in patients with HCC. (A) The oncoprint analysis of FGA, FGB, and FGG expression in patients with HCC using TCGA_LIHC arranged by the mRNA expression level. mRNA expression is represented as z-scores relative to diploid samples and categorized as high (z > 0) or low (z < 0). Genetic alterations are annotated separately. (B) Kaplan–Meier survival analysis was used to evaluate the effect of the fibrinogen family expression on overall survival (OS) (left) and disease-free survival (DFS) (right). (C) Proportions of alterations in the expression levels of the fibrinogen family members across different clinical characteristics. Left: Distribution of patients according to the histologic grades of the neoplasm. Right: Distribution of patients according to vascular invasion. Statistically significant differences were determined using unpaired Student’s t-test. (D) Kaplan–Meier survival curves assessing the prognostic impact of individual gene expression (FGA, FGB, FGG) and the combined expression profile (FGA + FGB + FGG) on OS (top row) and DFS (bottom row). Statistical differences were determined by log-rank test. All gene expression values were dichotomized by median expression levels. Statistically significant differences were determined using the log-rank test; * P < 0.05, ** P < 0.01. Data are shown as mean ± SD.