Fig. 6
From: Fibrinogen alpha and beta chains as non-invasive predictors of hepatocellular carcinoma progression
Investigation of fibrinogen expression in the HCC tumor microenvironment. (A) Immune cell infiltration analysis using TIMER 2.0 (http://timer.comp-genomics.org/timer/). Correlation analysis of fibrinogen family expression with the tumor purity and MDSC cells in TCGA_LIHC. (B) UMAP of immune-associated and malignant cells colored according to the cell types analyzed using 50,023 cells from 25 patients with HCC. TAMs, tumor-associated macrophages; TECs, tumor endothelial cells; CAFs, cancer-associated fibroblasts; Tregs, regulatory T cells; MDSCs, myeloid-derived suppressor cells. (C) Violin plots of cell-type specific FGA, FGB, and FGG expression. (D) UMAP plot of FGA, FGB, and FGG expression across the MDSCs colored according to the cell clusters. (E) The top 10 pathways analyzed by GSEA with fibrinogen-associated genes. (F) Biological and functional pathway analysis with the low expressed fibrinogen cells showing interferon alpha and gamma response performed using GSEA.
