Table 3 The MAVRiC Case Cohort study consisted of a sub-cohort (n = 561) randomly chosen from the TEDDY Celiac Cohort and the inclusion of all children with CD-Onset b before 4 years of age

From: Microbial associations and viruses on the risk of celiac disease (MAVRiC): a longitudinal post-hoc case-cohort study

 

TEDDY Celiac Cohort

MAVRiC Case-Cohort

Sub-cohort (random sample)

CD-Onset

Cases

N c

Total

N

CDA-only

N

(% of total)

CD-Onset

N

(% of total)

Non CDA

Nb

CDA-only

N a

CD-Onset

Cases

N ab

Total

6132

398 (6.5%)

306 (5.0%)

483

41

37

269

Country

US

2472

139 (5.6%)

91 (3.7%)

190

15

11

80

Finland

1398

95 (6.8%)

52 (3.7%)

116

13

5

47

Germany

388

23 (6.3%)

19 (5.2%)

37

2

2

17

Sweden

1894

141 (7.4%)

144 (7.6%)

140

11

19

125

Sex

Male

3130

191 (6.1%)

111 (3.5%)

248

19

11

100

Female

3002

207 (6.9%)

195 (6.5%)

235

22

26

169

HLA-DR-DQ

DR4-DQ8 only

2483

69 (2.8%)

41 (1.7%)

228

3

3

38

DR3-DQ2/DR4-DQ8

2366

157 (6.6%)

92 (3.9%)

170

18

9

83

DR3/DQ2/DR3/DQ3

1303

172 (13.2%)

173 (13.3%)

85

20

25

148

  1. a = Any child developing CDA and selected at random into sub-cohort serves as a time-varying control before CDA development.
  2. b = CD-onset are children developing CDA before age 4-years and subsequently diagnosed with celiac disease.
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