Fig. 1
From: Establishing and validating a new metabolic marker-driven prognosis signature for cutaneous melanoma
Genetic and transcriptional alterations and functional analysis of MRGs in SKCM. (A) Analysis of somatic mutation rates across 39 melanoma-related genes (MRGs) in patients with SKCM, highlighting the genetic variability within this cohort. (B) Functional enrichment analysis of MRGs using GO and KEGG pathways. (C) Frequency of CNV gain and loss in MRGs. (D) Orientation of CNV changes in MRGs across 23 chromosomes. (E) Comparative expression profiles of MRGs between normal skin and SKCM samples. (F) Network diagram depicting interactions among MRGs in SKCM. Lines between genes represent their interrelations; pink indicates positive correlations, whereas blue indicates negative correlations. (*p < 0.05; **p < 0.01; and ***p < 0.001).
