Table 2 Twelve runs PBD used to screen the C–C cross-coupling reactions. The design has two levels for each factor: low (–1) and high (+ 1). Y is the conversion of substrate to product30.
From: Application of statistical design of experiment to identify key factors in cross coupling reactions
Factors | levels | |||||
|---|---|---|---|---|---|---|
A | B | C | D | E | Y | |
Runs | Electronic effect | Tolman angle | Catalyst loading | Base strength | Solvent polarity | % |
1 | + 1 | + 1 | –1 | + 1 | –1 | Y1 |
2 | + 1 | –1 | + 1 | + 1 | –1 | Y2 |
3 | –1 | + 1 | + 1 | + 1 | + 1 | Y3 |
4 | + 1 | + 1 | + 1 | –1 | + 1 | Y4 |
5 | + 1 | + 1 | –1 | –1 | + 1 | Y5 |
6 | + 1 | –1 | –1 | –1 | –1 | Y6 |
7 | –1 | –1 | –1 | + 1 | + 1 | Y7 |
8 | –1 | –1 | + 1 | –1 | –1 | Y8 |
9 | –1 | + 1 | –1 | + 1 | –1 | Y9 |
10 | + 1 | –1 | + 1 | + 1 | + 1 | Y10 |
11 | –1 | + 1 | + 1 | –1 | –1 | Y11 |
12 | –1 | –1 | –1 | –1 | + 1 | Y12 |
Σ{Y(–1)} | ȳ–1 A | ȳ–1B | ȳ–1 C | ȳ–1D | ȳ–1E | |
Σ{Y(+ 1)} | ȳ+1 A | ȳ+1B | ȳ+1 C | ȳ+1D | ȳ+1E | |
Estimated. effect | 2.ΔA/n | 2.ΔB/n | 2.ΔC/n | 2.ΔD/n | 2.ΔE/n | |
Disentangled. Effect | - | - | - | - | - |
