Fig. 7 | Scientific Reports

Fig. 7

From: Therapeutic efficacy of oncolytic adenovirus YSCH-01 in osteosarcoma evaluated in PDX and CDX mouse models

Fig. 7The alternative text for this image may have been generated using AI.

Activation of the type I interferon signaling pathway in YSCH-01-infected CDX tissue. (A) RNA-seq data analysis of CDX tumor tissue samples using 143B cell line, comparing the YSCH-01 treatment group to control groups. receiving This analysis revealed 394 genes up-regulated and 644 genes down-regulated in the treatment group compared to the control group. (B) Gene Ontology analysis showing significant gene expression enrichment in the ‘ISG15-protein conjugation’ and ‘response to type I interferon’ pathways, which are closely related to type I interferon activation in the YSCH-01 treatment group compared to the control group. (C) qPCR analysis showing the relative expression levels of the selected genes of ‘ISG15-protein conjugation’ and ‘response to type I interferon’ pathway showed in panel B.

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