Table 1 Baseline characteristics of BACLO-PTSD patients at the time of the BACLO-REA study (June 2016 to February 2019).

From: Effect of high-dose baclofen on post-traumatic stress disorder symptoms five years after hospitalization among critically ill patients with unhealthy alcohol use

Characteristics

Baclofene

N = 46

Placebo

N = 48

p-value

Age, Median (IQR)

54.5 [43 ;65]

57 [45.5;62.5]

0.56

Sex : Male, n (%)

37 (80.4%)

44 (91.7%)

0.11

Body Mass Index, Median (IQR)

25.7 [22.3;28.8]

28.5 [22.4;31.5]

0.76

SAPS II a, Median (IQR)

42 [29 ;48]

40 [32 ;52.5]

0.79

SOFAb, Median (IQR)

7 [4 ;10]

6 [3 ;10]

0.90

Diabetes, n (%)

4 (8.7%)

7 (14.6%)

0.37

Cirrhosis, n (%)

0 (0%)

1 (2.1%)

0.99

Characteristics of substance use

Tobacco, n (%)

28 (60.9%)

27 (56.3%)

0.65

Units of alcohol intake per day c,

Median (IQR)

6 [4 ;10]

5 [3 ;10]

0.30

Prior alcohol withdrawal attempts d, n (%)

13 (28.3%)

7 (14.6%)

0.10

Alcohol abuse e, n (%)

16 (34.8%)

18 (37.5%)

0.94

Alcohol dependencee, n (%)

14 (30.4%)

11 (22.9%)

0.39

Drugs use d, n (%)

4 (8.7%)

0 (0%)

0.053

Hospitalization informations

Reason for ICU admission, n (%)

  

0.29

Medical

36 (78.3%)

33 (68.8%)

 

Surgical

10 (21.7%)

15 (31.3%)

 

Diagnosis leading to hospitalization n (%)

Acute respiratory distress syndrom

18 (39.1%)

17 (35.4%)

 

Septic shock

9 (19.6%)

6 (12.5%)

 

Trauma

6 (13.0%)

10 (20.8%)

 

Altered Mental statusf

3 (6.5%)

1 (2.1%)

 

Overdose or toxic ingestion

0 (0%)

2 (4.2%)

 

Pancreatidis

4 (8.7%)

4 (8.3%)

 

Delirium tremens

1 (2.2%)

3 (6.3%)

 

Postoperative care

3 (6.5%)

2 (4.2%)

 

Pneumonia

2 (4.3%)

1 (2.1%)

 

Hemorragic shock

0 (0%)

1 (2.1%)

 

Acute liver failure

0 (0%)

1 (2.1%)

 
  1. aThe Simplified Acute Physiology Score (SAPS) II ranges from 0 to 163, with higher scores indicating a greater severity of illness. It was calculated using age, type of admission (emergency surgery, elective surgery, medical patient), chronic diseases (acquired immunodeficiency syndrome, metastatic cancer, hematological malignancy), and the worst value for 12 physiological variables within the 24 h after admission.
  2. bThe Sequential Organ Failure Assessment (SOFA) score was used to assess the degree of dysfunction of 6 organ systems: respiratory, cardiovascular, coagulation, renal, neurologic, and hepatic. Each subscore ranges from 0 (healthy) to 4 (maximum severity of organ dysfunction). The overall score ranges from 0 to 24.
  3. cBased on medical record or patient or next of kin declaration and was assessed according to the “standard” drink definition from the National Institute on Alcohol Abuse and Alcoholism (NIAAA; namely 1 unit contains approximately 14 g of alcohol).
  4. dBased on medical record or patient or next of kin declaration.
  5. ePatients were subjected to the questionnaire of the Diagnostic and Statistical Manual of Mental Disorder, 4th Edition, adapted by the NIAAA, to detect alcohol use disorder (ie, alcohol abuse or dependence). Alcohol abuse involves excessive drinking that negatively impacts health, relationships, and work, without physical dependence. Alcohol dependence includes these issues plus increased tolerance, withdrawal symptoms, and loss of control over drinking. The difference is the presence of physical dependence in alcohol dependance, causing more severe disruptions in daily life.
  6. fAltered mental status was defined as Glasgow Coma Scale (GCS) score less than 15. The GCS score is the sum of scores for eye, verbal, and motor responses. The minimum score is 3, which indicates deep coma, and the maximum is 15, which indicates fully awake.
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