Fig. 1
From: ASS1 facilitates T-ALL progression via the arginine-mediated mTORC1/c-Myc signaling pathway
ASS1 high expression in T-ALL correlates with adverse prognosis. A. mRNA expression levels of ASS1 in T-ALL RNA-seq databases (GEO, GSE26713). Dataset includes 7 normal bone marrow (BM) and 117 T-ALL samples. Y-axis represents the normalized expression values (log₂-transformed signal intensities) obtained from microarray analysis (RMA normalization). B. mRNA expression levels of ASS1 in ALL RNA-seq databases (GEO, GSE13425), n = 190. Y-axis represents the normalized expression values (log₂-transformed signal intensities) obtained from microarray analysis (RMA normalization). C The qPCR analysis of ASS1 expressions in T-ALL cell lines versus normal T cells. The Y-axis shows fold change relative to Normal-T1. D Protein expression levels of ASS1 in T-ALL cell lines and normal T cells. E Event-free survival in ALL patients stratified by ASS1 expression (n = 256, dbGaP, phs000463 and phs000464). Data are mean ± SD (Two-tailed unpaired student’s t-test, *** p < 0.001).
