Fig. 2
From: ASS1 facilitates T-ALL progression via the arginine-mediated mTORC1/c-Myc signaling pathway
ASS1 depletion suppresses T-ALL proliferation and induces apoptosis. A-C. ASS1 Protein expression and proliferation curves of (A) Jurkat cells, (B) MOLT-4 cells, (C) KE-37 cells following ASS1 knockdown. The knockdown efficiency of T-ALL cells was detected at 72 h after transfection with the shASS1 lentiviral vector, and cell counting was performed on Day 3, 5, and 7 after transfection. D. ASS1 Protein expression and proliferation curves of Jurkat ASS1 knockdown cells, and ASS1-knockdown & overexpression cells. E. Apoptosis analysis in Jurkat cells following ASS1 knockdown. Apoptosis was quantified at 72 h after transfection with ASS1-sh1 lentiviral vector. F. Apoptosis analysis in MOLT-4 cells following ASS1 knockdown. Apoptosis was detected 72 h after transfection with ASS1-sh1 lentiviral vector. Data are mean ± SD (Two-tailed unpaired Student’s t-test, * p < 0.05, ** p < 0.01, *** p < 0.001).
