Fig. 6
From: ASS1 facilitates T-ALL progression via the arginine-mediated mTORC1/c-Myc signaling pathway
c-Myc overexpression rescues proliferation defects in ASS1-deficient T-ALL cells. A-C Protein expression and proliferation analysis in ASS1-knockdown T-ALL cells with c-Myc overexpression: (A) Jurkat, (B) MOLT-4, (C) KE-37. T-ALL cells were collected at 72 h after transfection using lentivirus vectors. The y-axis represents fold change relative to Day 3 controls. D Schematic diagram illustrating the mechanism of ASS1-mediated regulation through arginine-mediated mTORC1/c-Myc signaling. Data are mean ± SD (two-tailed unpaired student’s t-test, * p < 0.05, ** p < 0.01).
