Table 3 Cox regression analysis for mortality.

From: Low levels of serum albumin and blood basophils as 10-year mortality predictors in a nationwide Korean COPD cohort

Variables

No. of Missing

Unadjusted

Adjusted with age, sex, smoking status, TB history, BMI, FEV1, and mMRC

Adjusted with age, sex, smoking status, TB history, BMI, FEV1, mMRC, CCI*, 6-minute walk test*, and past history of exacerbation*

 

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

WBC (x103/uL)

12

1.073 (1.026–1.122)

0.002

1.039 (0.994–1.085)

0.089

  

Hemoglobin (g/dL)

0

0.814 (0.760–0.871)

< 0.001

0.865 (0.803–0.930)

< 0.001

0.879 (0.817–0.946)

< 0.001

Hematocrit (%)

14

0.937 (0.917–0.958)

< 0.001

0.949 (0.926–0.973)

< 0.001

0.955 (0.931–0.979)

< 0.001

Platelet (x103/uL)

18

0.999 (0.997–1.000.997.000)

0.159

    

Neutrophil (%)

61

1.025 (1.015–1.036)

< 0.001

1.012 (1.002–1.022)

0.023

1.010 (1.000–1.020.000.020)

0.055

Lymphocyte (%)

55

0.967 (0.955–0.980)

< 0.001

0.987 (0.974–0.999)

0.040

0.990 (0.978–1.002)

0.114

Monocyte (%)

53

1.007 (0.976–1.038)

0.676

    

Eosinophil (%)

54

0.961 (0.923–1.001)

0.058

    

Basophil (%)

51

0.459 (0.325–0.647)

< 0.001

0.622 (0.448–0.864)

0.005

0.655 (0.472–0.908)

0.011

Creatine (mg/dL)

116

1.229 (1.072–1.410)

0.003

1.194 (1.018–1.401)

0.029

1.181 (1.009–1.383)

0.038

Total protein (g/dL)

166

0.706 (0.569–0.876)

0.002

0.878 (0.709–1.086)

0.230

  

Albumin (g/dL)

161

0.379 (0.307–0.468)

< 0.001

0.469 (0.366–0.602)

< 0.001

0.465 (0.362–0.599)

< 0.001

AST (IU/L)

165

1.003 (0.997–1.008)

0.377

    

ALT (IU/L)

166

0.995 (0.986–1.004)

0.272

    

Total bilirubin (mg/dL)

167

0.902 (0.656–1.239)

0.524

    

BUN (mg/dL)

143

1.027 (1.012–1.043)

< 0.001

1.019 (1.002–1.035)

0.025

1.017 (1.000–1.033.000.033)

0.046

  1. *Multiple imputation was used to handle missing data of them.
  2. * All analysis were conducted separately.
  3. TB, tuberculosis; BMI, body mass index; FEV1, forced expiratory volume in 1 s; mMRC, modified Medical Research Council dyspnea scale; CCI, Charlson Comorbidity Index; HR, hazard ratio; CI, confidence interval; WBC, white blood cell; ESR, erythrocyte sedimentation rate; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; BUN, blood urea nitrogen; NT-proBNP, N-terminal pro brain-natriuretic peptide.
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