Fig. 2 | Scientific Reports

Fig. 2

From: Tie1 derived from cervical cancer promotes the invasion and metastasis by Ang1 mediating Tie2/PI3K/Akt signaling axis and angiogenesis

Fig. 2

Tie1 knockdown inhibited the migration, invasion, and proliferation of cervical cancer cells, which was partially reversed by Ang1. (A) Effect of Tie1 knockdown on the proliferation of HeLa and SiHa cells was evaluated. (B) The effect of Tie1 knockdown on cell migration was assessed using a wound healing assay in HeLa and SiHa cells. Scale bar = 200 μm. (C) The impact of Tie1 knockdown on the invasion capacity of HeLa and SiHa cells was evaluated using a Transwell assay. Scale bar = 50 μm. (D) Effect of Tie1 knockdown on the tube-forming capacity of Huvec cells was investigated. Data are shown as mean ± SD of 3 independent experiments. Statistical significance was assessed by one-way ANOVA with Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001.

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