Table 2 Correlation of CD44 expression with clinicopathological parameters in colorectal carcinoma.

From: CD44 and phosphorylated ERK1/2 coexpression predicts distant metastasis in colorectal cancer based on a study of 1137 Saudi patients

 

CD44 high

CD44 low

p value

n

%

n

%

Total Number of Cases

542

47.7

595

52.3

 

Age

 ≤ 50 years

190

35.1

185

31.1

0.1557

 > 50 years

352

64.9

410

68.9

 

Gender

 Male

289

53.3

308

51.8

0.5997

 Female

253

46.7

287

48.2

 

Histological subtype

 Adenocarcinoma

474

87.4

540

90.8

0.0734

 Mucinous Carcinoma

68

12.6

55

9.2

 

Histological grade

 Well differentiated

42

7.9

60

10.4

0.0111

 Moderately differentiated

425

79.7

475

82.2

 

 Poorly differentiated

66

12.4

43

7.4

 

Tumor Site

 Left colon

442

81.5

482

81.0

0.8152

 Right colon

100

18.5

113

19.0

 

pT

 T1

24

4.5

21

3.6

0.7052

 T2

87

16.2

87

14.9

 

 T3

374

69.6

409

70.3

 

 T4

52

9.7

65

11.2

 

pN

 N0

237

44.1

310

53.2

0.0042

 N1

177

33.0

176

30.2

 

 N2

123

22.9

97

16.6

 

Metachronous distant metastasis

 Present

96

17.7

85

14.3

0.1147

 Absent

446

82.3

510

85.7

 

Tumour Stage

 I

77

14.2

89

15.0

0.0045

 II

148

27.3

206

34.8

 

 III

251

46.3

214

36.2

 

 IV

66

12.2

83

14.0

 

MMR status

 dMMR

66

12.2

38

6.4

0.0007

 pMMR

476

87.8

557

93.6

 

Ki-67 expression

 High

361

67.6

339

59.5

0.0051

 Low

173

32.4

231

40.5

 

p-ERK1/2 expression

 High

283

54.5

254

44.7

0.0012

 Low

236

45.5

314

55.3

 
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