Fig. 4 | Scientific Reports

Fig. 4

From: Single-cell identification of an endothelial cell proximal SPP1+ macrophage population defines the metastatic vascular niche in lymph nodes

Fig. 4

SPP1+ TAMs exhibit strong interaction with endothelial cells in metastatic lymph nodes. (A) UMAP visualization of ECs populations. Left: Cells colored by subtype classification. Right: Cells colored by tissue origin. (B) Dot plot showing expression patterns of canonical EC marker genes across identified subpopulations. (C) Bar plot comparing GSVA enrichment scores between LN and MET ECs. Statistical analysis performed using limma. (D) Dot plot visualization of predicted ligand-receptor interactions between TAM1_SPP1 and BECs or LECs.

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