Table 2 Pregnancy outcomes with and without assisted hatching (AH) before propensity score weighting. P-values for categorical variables were obtained using the chi-squared test.

From: Effect of assisted hatching on pregnancy outcomes following 1,678,872 single embryo transfers based on the Japan Assisted Reproductive Technology Registry

 

AH

(924,142 cycles)

Non-AH

(754,730 cycles)

Risk difference (%)

P value

Cycles

(%)

Cycles

(%)

Primary outcomes

 Clinical pregnancy

302,918

32.78

211,570

28.03

4.75

< 0.0001

 Live birth

214,555

23.22

153,375

20.32

2.89

< 0.0001

Secondary outcomes

 Miscarriage

78,788

26.01

50,981

24.10

1.91

< 0.0001

 Ectopic pregnancy

1746

0.19

1760

0.23

-0.04

< 0.0001

 Placenta previa

2334

1.09

1858

1.21

-0.12

0.0005

 Placenta accreta spectrum

1821

0.85

689

0.45

0.40

< 0.0001

 Multiple pregnancy

4025

1.33

2336

1.10

0.22

< 0.0001