Table 2 Univariate and multivariable analysis of risk factors associated with disease-free survival.
From: Prognostic value of preoperative serum ferritin in cholangiocarcinoma patients
Variables | Values | Univariate hazard ratio (95% CI) | P-value | Multivariate hazard ratio (95% CI) | P-value |
|---|---|---|---|---|---|
Age(years) | ≤ 60/>60 | 1. 1.396 (0.851–2.288) | 0.172 | ||
Gender | Female/Male | 0.982 (0.599–1.609) | 0.941 | ||
Ferritin(ng/ml) | ≤ 196.5/>196.5 | 2.871 (1.740–4.735) | 0.000 | 4.021 (1.680–9.626) | 0.001 |
CA19-9(KU/L) | ≤ 105/>105 | 1.950 (1.182–3.218) | 0.005 | 1.944 (1.041–3.632) | 0.037 |
CA125(KU/L) | ≤ 22.3/>22.3 | 1.813 (1.029–3.196) | 0.018 | 0.687 (0.358–1.321) | 0.261 |
CEA(ng/ml) | ≤ 5/>5 | 2.284 (1.142–4.570) | 0.002 | 1.602 (0.833–3.081) | 0.158 |
PA(mg/L) | ≤ 229.5/>229.5 | 1.800 (0.989–3.279) | 0.024 | 1.491 (0.800-2.778) | 0.208 |
ALB(g/L) | ≤ 35/>35 | 0.860 (0.498–1.483) | 0.570 | ||
Tbil(µmol/L) | ≤ 34.2/>34.2 | 0.612 (0.364–1.027) | 0.045 | 0.423 (0.209–0.857) | 0.017 |
Ki-67(%) | ≤ 30/>30 | 2.318 (1.383–3.884) | 0.000 | 2.228 (1.237–4.013) | 0.008 |
CD34/31 | No/Yes | 0.709 (0.425–1.182) | 0.206 | ||
NLR | ≤ 3.5/>3.5 | 1.064 (0.636–1.782) | 0.809 | ||
LMR | ≤ 4/>4 | 1.633 (0.940–2.838) | 0.053 | ||
PLR | ≤ 138.5/>138.5 | 0.573 (0.324–1.014) | 0.028 | 0.887 (0.429–1.831) | 0.745 |
Lymphatic metastasis | N1-2/N0 Nx/N1-2 Nx/N0 | 1.849 (0.963–3.549) | 0.040 | 1.849 (0.963–3.549) | 0.040 |
1.827 (0.952–3.505) | 0.046 | ||||
2.841 (1.403–5.753) | 0.000 | 2.841 (1.403–5.753) | 0.000 | ||
Vascular invasion | No/Yes | 1.214 (0.726–2.122) | 0.932 | ||
Differentiated degree | Low | 0.530 | |||
Low-medium | 0.618 (0.198–1.925) | 0.305 | |||
Medium | 0.746 (0.249–2.235) | 0.563 | |||
Medium-high | 0.609 (0.181–2.056) | 0.363 | |||
High | 0.313 (0.070–1.392) | 0.110 | |||
Postoperative adjuvant therapy | No/Yes | 0.601 (0.368–0.981) | 0.043 | 0.640 (0.363–1.129) | 0.123 |
