Table 3 Correlation matrix of key variables affecting LE % and EE %.

From: Predictive optimization of curcumin nanocomposites using hybrid machine learning and physics informed modeling

Variable

r (LE %)

r (EE %)

p

Interpretation

\(D_{p}\)

 − 0.43

 − 0.39

 < 0.01

Smaller particles ↑ loading via greater surface area

ζ

 + 0.22

 + 0.20

 < 0.05

Higher

\(R_{{\frac{poly}{{lipid}}}}\)

 + 0.61

 + 0.53

 < 0.01

Strong positive effect on encapsulation

\(C_{surf }\)

 + 0.58

 + 0.49

 < 0.01

Improves micellar solubilization

PEGylation (binary)

 + 0.34

 + 0.28

 < 0.05

Enhances steric stability

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