Fig. 1 | Scientific Reports

Fig. 1

From: LINC01116 promotes nascent protein synthesis and cellular stemness through the miR-432-5p/FKBP7/14 regulatory axis in melanoma

Fig. 1

LINC01116-Associated Differentially Expressed Genes and Pathways (A) Volcano plot of differentially expressed genes (DEGs) in melanoma from the GEO#GSE15605, highlighting LINC01116 upregulation. (B) Validation of LINC01116 overexpression in melanoma using TCGA-derived DEG volcano plot. (C) Kaplan-Meier survival curve demonstrating reduced 8-year overall survival in melanoma patients with high LINC01116 expression. (D) Spearman correlation Scatter Plot of LINC01116 co-expressed genes (|cor| >0.2, P < 0.05). (E) Venn diagram intersecting LINC01116-correlated genes, melanoma co-expressed genes, and DEGs, identifying 129 overlapping genes. (F) KEGG pathway enrichment analysis of the 129 overlapping genes, highlighting cancer-related signaling pathways.

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