Fig. 1 | Scientific Reports

Fig. 1

From: LEM4 interacts with β-catenin and promotes β-catenin-dependent transcription activity to confers ribociclib resistance in breast cancer cells

Fig. 1

Expression of LEM4 in breast cancer tissues and cell lines. (A) Comparison of LEM4 mRNA levels between matched tumor specimens and normal counterparts (n = 60 pairs). Significantly elevated LEM4 expression was observed in tumor tissues, paired Student’s t-test. (B) Immunoblotting analysis demonstrating overexpression of LEM4 protein in breast cancer tumor specimens. (C) Kaplan-Meier survival curve showing worse overall survival in breast cancer patients with high LEM4 expression (n = 60 patients, stratified by the median level of qPCR detection). (D) Increased protein levels of LEM4 in breast cancer cell lines (MCF-7, T47D) compared to a normal breast epithelial cell line (MCF-10 A). Data are summary of 3 independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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