Fig. 7 | Scientific Reports

Fig. 7

From: LEM4 interacts with β-catenin and promotes β-catenin-dependent transcription activity to confers ribociclib resistance in breast cancer cells

Fig. 7

LEM4 knockdown and ribociclib treatment in vivo. (A) Tumor images showing significant reduction in tumor mass formed by drug-resistant cells after LEM4 knockdown under ribociclib treatment conditions. (B) Weights of tumors from different experimental groups, demonstrating suppressed tumor growth in LEM4 knockdown group under ribociclib treatment. (C) TUNEL staining revealing increased apoptotic events in drug-resistant tumors after LEM4 silencing. (D) Immunoblotting analysis showing reduced nuclear β-catenin levels in drug-resistant tumors upon LEM4 knockdown. (E) Significant suppression of β-catenin target gene expression in ribociclib-resistant tumor tissues after LEM4 knockdown. N = 5 animals in each group. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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