Fig. 3 | Scientific Reports

Fig. 3

From: Epigenetic and transcriptomic alterations precede amyloidosis in the Alzheimer’s disease AppNL-G-F knock-in mouse model

Fig. 3

Gene expression changes in AppNL-G-F hippocampus precede severe Aβ pathology and highlight brain dynamics during disease progression. (A) A table summarizes differentially expressed genes (DEGs) across timepoints of pathology and a Venn diagram illustrates DEGs shared across timepoints (B) Selected significantly enriched gene ontology (GO) terms for DEGs at each timepoint highlight key pathway shifts during disease progression. (C) Clustering of genes with significant genotype-by-age interactions reveals major trajectories of gene expression changes throughout disease progression.

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