Fig. 4
From: Genomic analysis unlocks the potential of denosumab as a targeted therapy for Crohn’s disease
Gene set enrichment analysis of disease ontology associations using OpenXGR. Bubble plot showing enriched disease terms identified through gene set enrichment analysis. The x-axis represents the Z-score, and the y-axis represents –log10(FDR). Bubble size indicates the number of associated genes. Among the top five enriched diseases, Crohn’s disease (CD) exhibited the highest Z-score (12) and the strongest odds ratio (OR = 6.93, 95% CI [4.69–10.1], FDR = 2.20E–16), indicating the most robust association. Data were obtained from the OpenXGR platform (http://www.openxgr.com/OpenXGR).
