Fig. 4
From: Maternal urinary metabolomic signatures preceding spontaneous preterm birth: A pilot study
Network illustrating metabolic pathways, enzymes, and differential regulation of oxylipins across term and preterm births. The figure depicts the metabolic pathway of the differentially regulated oxylipins identified in this study, showing the relationships between precursors, products, and the enzymes mediating their conversion. The network illustrates the metabolism of (a) AA, (b) EPA, (c) DHA, and (d) LA. Arrows represent the enzymatic reactions mediated by the LOX, CYP450, or sEH enzymes, indicating the directionality of metabolite conversions. The network highlights the differential regulation of oxylipins across the following analyses: (i) overall preterm vs. term, (ii) non-infectious preterm vs. term, and (iii) infectious preterm vs. term. Each node represents a metabolite, color-coded to reflect its direction of regulation (upregulated or downregulated) in the preterm group compared to the term and its significance, based on univariate linear regression analysis. AA = arachidonic acid; EPA = eicosapentaenoic acid; DHA = docosahexaenoic acid; LA = linoleic acid; LOX = lipoxygenase; CYP450 = cytochrome P450; sEH = soluble epoxide hydrolase; DiHETrE = dihydroxyeicosatrienoic acid; EpETrE = epoxyeicosatrienoic acid; HETE = hydroxyeicosatetraenoic acid; DiHETE = dihydroxyeicosatetraenoic acid; EpETE = epoxyeicosatetraenoic acid; HEPE = hydroxyeicosapentaenoic acid; HDoHE = hydroxydocosahexaenoic acid; HODE = hydroxyoctadecadienoic acid.
