Table 3 Logistic regression analysis of factors associated to use of at least one LiverTox A drug.

From: Drug-related hepatotoxicity risk in elderly patients with atrial fibrillation: insights from the nationwide Italian START registry

Characteristics

Univariable Analysis

Multivariable Analysis

OR

95% CI

p-value

OR

95% CI

p-value

Sex (Male)

1.29

1.18, 1.41

 < 0.001

1.09

0.97, 1.22

0.134

Age (Over 90)

0.65

0.57, 0.74

 < 0.001

0.54

0.45, 0.65

 < 0.001

Geographic Area (vs North)

      

Centre

1.00

0.90, 1.11

0.984

0.99

0.86, 1.14

0.928

South

1.43

1.24, 1.66

 < 0.001

1.18

0.99, 1.41

0.067

BMI ≥ 25

1.28

1.16, 1.40

 < 0.001

1.21

1.07, 1.37

0.002

Family history of cardiovascular disease

1.13

0.96, 1.32

0.154

1.03

0.85, 1.25

0.728

Cancer

1.08

0.95, 1.22

0.243

0.99

0.85, 1.16

0.930

Diabetes

2.18

1.95, 2.44

 < 0.001

1.62

1.41, 1.86

 < 0.001

Hypertension

2.10

1.87, 2.37

 < 0.001

1.30

1.11, 1.51

 < 0.001

Previous cerebral vasculopathy

1.56

1.39, 1.76

 < 0.001

1.40

1.20, 1.62

 < 0.001

Ischemic heart disease

5.31

4.67, 6.06

 < 0.001

4.88

4.15, 5.76

 < 0.001

Heart Failure

1.54

1.36, 1.74

 < 0.001

1.19

1.01, 1.40

0.034

Peripheric Vasculopathy

1.66

1.39, 2.00

 < 0.001

1.26

0.99, 1.61

0.060

Chronic Respiratory Disease

1.49

1.31, 1.70

 < 0.001

1.23

1.05, 1.45

0.012

Kidney Function Class (vs Cl Creatinine > 60 ml/min)

      

Decreased (30–59)

1.15

1.05, 1.26

0.002

1.29

1.14, 1.47

 < 0.001

Severely decreased (< 30)

1.45

1.18, 1.77

 < 0.001

1.68

1.27, 2.24

 < 0.001

Either transaminasis increased

1.08

0.92, 1.27

0.348

0.97

0.81, 1.17

0.775

  1. OR: Odds Ratio; CI: Confidence Interval.
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