Table 4 Logistic Regression Analysis of LiverTox A drugs use with increased transaminases (Only drugs taken by at least 5 patients were considered).

From: Drug-related hepatotoxicity risk in elderly patients with atrial fibrillation: insights from the nationwide Italian START registry

LiverTox A drug

N Patients (%)

Univariable

Multivariable*

  

OR

95% CI

p-value

OR

95% CI

p-value

Atorvastatin

1128 (13.73)

1.14

0.91, 1.41

0.257

1.19

0.94, 1.49

0.140

Amiodarone

925 (11.26)

1.63

1.31, 2.02

 < 0.001

1.61

1.29, 2.00

 < 0.001

Simvastatin

807 (9.82)

0.61

0.44, 0.82

0.002

0.60

0.43, 0.82

0.002

Allopurinol

626 (7.62)

0.92

0.66, 1.25

0.603

0.99

0.71, 1.35

0.949

Rosuvastatin

358 (4.36)

1.15

0.79, 1.64

0.447

1.19

0.81, 1.70

0.349

Methimazole

118 (1.44)

1.77

1.01, 2.91

0.033

1.83

1.04, 3.03

0.026

Ticlopidine

113 (1.38)

0.49

0.17, 1.10

0.126

0.54

0.19, 1.21

0.183

Valproate

30 (0.37)

0.42

0.02, 2.02

0.402

0.45

0.03, 2.16

0.436

Carbamazepine

28 (0.34)

0.39

0.02, 1.84

0.355

0.39

0.02, 1.84

0.352

Methotrexate

23 (0.28)

2.35

0.67, 6.42

0.128

2.18

0.61, 6.13

0.173

Ibuprofen

19 (0.23)

1.34

0.21, 4.80

0.701

1.05

0.16, 3.95

0.950

Phenytoin

13 (0.16)

0.85

0.05, 4.38

0.877

1.03

0.06, 5.42

0.976

Azathioprine

10 (0.12)

1.87

0.10, 11.60

0.567

1.61

0.08, 10.10

0.667

Diclofenac

7 (0.09)

1.56

0.08, 9.15

0.681

1.49

0.08, 9.07

0.719

Levofloxacin

6 (0.07)

1.87

0.10, 11.6

0.567

2.42

0.12, 16.50

0.431

  1. OR = Odds Ratio, CI = Confidence Interval. *adjusted for CHA₂DS₂-VASc score, creatinine clearance, body mass index, and the presence of cirrhosis with oesophageal varices.
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