Table 3 Longitudinal associations of eGDR with frail incidence.

From: Estimated glucose disposal rate and frailty in middle and older aged adults from three prospective cohorts

Characteristic

CHARLS

ELSA

HRS

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Cumulative eGDR, per unit

0.97 (0.96, 0.98)

< 0.001

0.98 (0.98, 0.99)

< 0.001

0.99 (0.99, 0.99)

< 0.001

Cumulative eGDR, quartiles

      

Q1

Ref.

 

Ref.

 

Ref.

 

Q2

0.72 (0.60, 0.85)

< 0.001

0.81 (0.65, 1.00)

0.051

0.97 (0.81, 1.16)

0.733

Q3

0.52 (0.42, 0.64)

< 0.001

0.65 (0.51, 0.82)

< 0.001

0.79 (0.65, 0.96)

0.020

Q4

0.55 (0.44, 0.69)

< 0.001

0.58 (0.43, 0.79)

< 0.001

0.63 (0.49, 0.81)

< 0.001

P for trend

< 0.001

 

< 0.001

 

< 0.001

 

Change in the eGDR

      

Class 1

Ref.

 

Ref.

 

Ref.

 

Class 2

1.57 (1.33, 1.86)

< 0.001

1.34 (1.04, 1.72)

0.022

1.45 (1.22, 1.72)

< 0.001

Class 3

1.48 (1.04, 2.10)

0.029

1.06 (0.88, 1.27)

0.57

0.97 (0.74, 1.27)

0.803

P for trend

< 0.001

 

0.404

 

0.057

 
  1. Adjusted covariates include age, sex, marital status, education, smoking status, drinking status, BMI, HDL-C, hsCRP, diabetes, and obesity.
  2. BMI, body mass index; CHARLS, China Health and Retirement Longitudinal Study; CI, confidence interval; ELSA, English Longitudinal Study of Ageing; CRP, C-reactive protein; HDL-C, high-density lipoprotein cholesterol; HR, Hazard Ratio; SD, standard deviation.
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