Table 1 Characteristics of the individual case safety reports (ICSRs) of drugs used in pain therapies stratified by age.
From: Age disparities in adverse reactions of drugs used in pain therapies in Switzerland
All adults | Younger adults (18–74 years) | Older adults (75 + years) | |
|---|---|---|---|
Counts, No. (%) | Counts, No. (%) | Counts, No. (%) | |
ICSRs | 17,228 (100.0) | 13,183 (76.5) | 4045 (23.5) |
Sex | |||
Male | 7172 (41.6) | 5608 (42.5) | 1564 (38.7) |
Female | 10,056 (58.4) | 7575 (57.5) | 2481 (61.3) |
Age | |||
Mean (SD) | 58.2 (18.9) | 50.8 (15.1) | 82.0 (5.26) |
Median [Min, Max] | 59.0 [18.0, 113] | 52.0 [18.0, 74.0] | 81.0 [75.0, 113] |
Serious | |||
Yes | 9939 (57.7) | 7145 (54.2) | 2794 (69.1) |
No | 3673 (21.3) | 3098 (23.5) | 575 (14.2) |
Missing | 3616 (21.0) | 2940 (22.3) | 676 (16.7) |
Fatal | |||
Yes | 913 (5.3) | 539 (4.1) | 374 (9.2) |
No | 16,315 (94.7) | 12,644 (95.9) | 3671 (90.8) |
Drug category | |||
Adjuvant pain medications | 4731 (27.5) | 3879 (29.4) | 852 (21.1) |
Antimigraine preparations | 3919 (22.7) | 3161 (24.0) | 758 (18.7) |
NSAIDs | 5784 (33.6) | 3917 (29.7) | 1867 (46.2) |
Opioids | 2123 (12.3) | 1595 (12.1) | 528 (13.1) |
Other drugs used in pain therapies | 3013 (17.5) | 2397 (18.2) | 616 (15.2) |
Number of reported drugs | |||
Median [Min, Max) | 3 [1, 42] | 3 [1, 42] | 5 [1, 35] |
1 | 4290 (24.9) | 3711 (28.1) | 579 (14.3) |
2 | 2718 (15.8) | 2298 (17.4) | 420 (10.4) |
3 | 2010 (11.7) | 1683 (12.8) | 327 (8.1) |
4 + | 8210 (47.6) | 5491 (41.7) | 2719 (67.2) |
