Fig. 6
From: Rictor/mTORC2 signaling pathway mediates Benzo[a]pyrene-induced renal injury
Rictor/mTORC2 signaling axis mediates B[a]P-induced renal injury. (A) 420 differentially expressed genes were screened from the databases. (B) KEGG pathway enrichment analysis, generated using the KEGG database (https://www.kegg.jp/)75 with permission from Kanehisa Laboratories (License No. 253975). (C) GO enrichment analysis. (D) Docking View of B[a]P with Rictor. (E) Relative mRNA levels of Rictor, mTOR, AKT1 and PKC-ζ in kidney tissues of WT mice. (F) WT versus Mac Rictor-/- mice comparing the above molecular expression changes. Data are presented as mean ± SEM (n = 6). Asterisks (*) denote significant differences between the B[a]P group and the corresponding control group: *P < 0.05, **P < 0.01, ***P < 0.001. Hashtags (#) indicate significant differences across time points within the control or B[a]P-treated groups: #P < 0.05, ## P < 0.01, ### P < 0.001.
