Table 1 Baseline characteristics of subjects in the original and matched cohorts.

From: Hypothermia association with all-cause mortality in critically ill patients with sepsis based on the MIMIC-IV database

Covariates

Original cohort (N = 19636)

 

Matched cohort (N = 1858)

 

Normal

hypothermia

SMD

Normal

hypothermia

SMD

N

18,699

937

 

927

927

 

Age (Years)

68.0 (56.8, 79.0)

71.2 (58.7, 81.6)

0.141

70.5 (58.7, 81.4)

71.4 (58.8, 81.6)

0.002

Male (%)

10,755 (57.5%)

518 (55.3%)

0.045

537 (57.9%)

513 (55.3%)

0.052

Race (%)

  

0.079

  

0.042

White

12,950 (69.3%)

617 (65.9%)

 

100 (10.8%)

89 (9.6%)

 

Black

1492 (8%)

90 (9.6%)

 

196 (21.1%)

201 (21.7%)

 

Yellow

514 (2.7%)

26 (2.8%)

 

608 (65.6%)

612 (66.0%)

 

Others

3743 (20%)

204 (21.7%)

 

23 (2.5%)

25 (2.7%)

 

Marital status (%)

8434 (45.1%)

385 (41.1%)

0.081

381 (41.1%)

383 (41.3%)

0.004

Insurance (%)

9960 (53.3%)

582 (62.1%)

0.18

334 (36.0%)

350 (37.8%)

0.036

Admission_type (%)

  

0.201

  

0.002

Elective

4593 (24.6%)

171 (18.2%)

 

585 (63.1%)

586 (63.2%)

 

Emergency

10,029 (53.6%)

593 (63.3%)

 

166 (17.9%)

171 (18.4%)

 

Urgent

4077 (21.8%)

173 (18.5%)

 

176 (19.0%)

170 (18.3%)

 

Weight (Kg)

79.9 (67.0, 95.2)

76.2 (65.0, 90.0)

0.141

76.9 (63.7, 92.6)

76.2 (65.0, 90.2)

0.018

Vital signs

      

HR (beats/min)

85.4 (75.7, 97.2)

79.3 (69.4, 90.2)

0.377

79.8 (70.2, 90.3)

79.3 (69.4, 90.2)

0.012

RR (beats/min)

18.9 (16.7, 21.9)

18.5 (16.1, 22.0)

0.055

18.8 (16.4, 21.7)

18.5 (16.1, 21.9)

0.002

SBP (mmHg)

114 (105, 125)

110 (102, 119)

0.284

110 (102, 120)

110 (102, 119)

0.001

DBP (mmHg)

60.5 (54.7, 67.3)

60.1 (53.7, 66.3)

0.095

59.6 (54.4, 65.9)

60.1 (53.7, 66.3)

0.001

SpO2

97.2 (95.8, 98.5)

97.8 (96.0, 98.9)

0.015

97.6 (96.0, 98.8)

97.8 (96.1, 98.9)

0.001

Laboratory parameters

      

Glu (mg/dl)

131 (114, 158)

138 (117, 178)

0.12

139 (119, 178)

138 (117, 177)

0.056

HCT (%)

29.5 (25.3, 34.1)

28.4 (24.1, 33.6)

0.128

28.4 (24.4, 33.0)

28.5 (24.2, 33.7)

0.034

HGB (g/dL)

9.8 (8.4, 11.3)

9.4 (8.10, 11.1)

0.096

9.4 (8.1, 11.0)

9.50 (8.1, 11.1)

0.042

PLT (109/L)

162 (112, 226)

147 (95.0, 210)

0.004

147 (101, 215)

148 (96.0, 211)

0.004

WBC (109/L)

13.8 (10.0, 18.7)

14.3 (9.80, 19.8)

0.026

13.8 (9.80, 19.1)

14.2 (9.80, 19.7)

0.042

AG

16.0 (13.0, 19.0)

17.0 (14.0, 22.0)

0.365

18.0 (14.0, 22.0)

17.0 (14.0, 22.0)

0.006

Bicarbonate (mmol/L)

22.0 (19.0, 24.0)

19.0 (15.0, 23.0)

0.259

19.0 (16.0, 22.0)

19.0 (15.0, 23.0)

0.017

Calcium (mmol/L)

8.00 (7.50, 8.50)

7.80 (7.20, 8.40)

0.215

7.80 (7.30, 8.40)

7.80 (7.20, 8.40)

0.020

Chloride (mmol/L)

103 (99.0, 106)

104 (98.0, 107)

0.065

103 (99.0, 107)

104 (98.0, 107)

0.020

Sodium (mmol/L)

137 (134, 140)

137 (134, 140)

0.032

137 (134, 140)

137 (134, 140)

0.010

potassium (mmol/L)

4.40 (4.10, 4.90)

4.60 (4.20, 5.30)

0.038

4.70 (4.20, 5.30)

4.60 (4.20, 5.30)

0.015

Bun (mg/dL)

22.0 (15.0, 37.0)

29.0 (18.0, 48.0)

0.304

30.0 (18.0, 51.5)

29.0 (18.0, 48.0)

0.020

Cr (mg/dL)

1.10 (0.80, 1.70)

1.50 (0.90, 2.50)

0.194

1.50 (1.00, 2.50)

1.50 (0.90, 2.50)

0.050

INR

1.30 (1.20, 1.60)

1.50 (1.20, 2.00)

0.181

1.40 (1.20, 1.90)

1.40 (1.20, 1.90)

0.043

PT (s)

14.7 (12.9, 17.6)

16.2 (13.9, 21.2)

0.244

15.5 (13.4, 21.2-)

16.1 (13.9, 21.0)

0.055

PTT (s)

32.5 (28.2, 42.3)

39.8 (31.2, 61.2)

0.243

37.2 (29.6, 63.9)

39.6 (31.2, 60.3)

0.048

Urine output (mL)

1590 (974, 2410)

1240 (597, 2110)

0.15

1350 (683, 2180)

1250 (603, 2110)

0.009

Score system

      

SOFA score

3.00 (2.00, 4.00)

4.00 (2.00, 5.00)

0.324

4.00 (2.00, 5.00)

4.00 (2.00, 5.00)

0.004

SAPS II

37.0 (30.0, 47.0)

46.0 (36.0, 58.0)

0.606

46.0 (35.0, 57.0)

46.0 (36.0, 58.0)

0.039

Comorbidities (%)

      

MI

3159 (16.8%)

179 (19.1%)

0.058

163 (17.6%)

178 (19.2%)

0.042

CHF

5175 (27.6%)

317 (33.8%)

0.134

324 (35.0%)

311 (33.5%)

0.030

Cerebrovascular disease

2741 (14.6%)

121 (12.9%)

0.051

135 (14.6%)

119 (12.8%)

0.050

COPD

4843 (25.8%)

248 (26.4%)

0.013

230 (24.8%)

244 (26.3%)

0.035

Mild liver disease

2662 (14.2%)

185 (19.7%)

0.147

196 (21.1%)

181 (19.5%)

0.040

Diabetes without complication

4494 (24%)

204 (21.7%)

0.054

213 (23.0%)

199 (21.5%)

0.036

Diabetes with complication

1702 (9.1%)

74 (7.8%)

0.043

80 (8.6%)

74 (8.0%)

0.023

Renal disease

3916 (20.9%)

267 (28.4%)

0.176

287 (31.0%)

264 (28.5%)

0.054

Malignant cancer

2607 (13.9%)

99 (10.5%)

0.103

111 (12.0%)

99 (10.7%)

0.041

Severe liver disease

1359 (7.2%)

85 (9%)

0.066

84 (9.1%)

84 (9.1%)

< 0.001

AIDS

121 (0.6%)

8 (0.8%)

0.024

7 (0.8%)

7 (0.8%)

< 0.001

Advanced life support (%)

      

Mechanical ventilation

8760 (46.8%)

576 (61.4%)

0.297

542 (58.5%)

566 (61.1%)

0.053

CRRT

963 (5.1%)

135 (14.4%)

0.316

142 (15.3%)

130 (14.0%)

0.037

ECMO

38 (0.2%)

12 (1.2%)

0.126

7 (0.8%)

7 (0.8%)

< 0.001

Vasoactive agent

9492 (50.7%)

641 (68.4%)

0.366

596 (64.3%)

631 (68.1%)

0.080

  1. HR: heart rate, RR: respiratory rate, SBP: systolic blood pressure, DBP: diastolic blood pressure, SpO2: saturation of pulse oxygen, Glu: blood glucose, HCT: haematocrit, HGB: haemoglobin, PLT: platelet counts, WBC: white blood cell count, AG: anion gap, BUN: blood urea nitrogen, Cr: creatinine, INR: international normalized ratio, PT: prothrombin time, PTT: partial thromboplastin time, Sequential Organ Failure Assessment: SOFA, SAPS II: Simplified Acute Physiology Score II, MI: myocardial infarction, CHF: congestive heart failure, COPD: chronic obstructive pulmonary disease, AIDS: acquired immune deficiency syndrome, CRRT: continuous renal replacement therapy, ECMO: extracorporeal membrane oxygenation.
  2. .
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