Fig. 1

Cortical Activation Patterns During VFT in HC and CID Groups (FDR-corrected, p < 0.05). This figure depicts the spatial distribution of significant cortical activation (oxy-hemoglobin changes) during the VFT in HC(top panels) and patients with CID (bottom panels), corrected for multiple comparisons using the FDR method (p < 0.05). The left (L) and right (R) hemispheres are shown separately. In the HC group, robust activation is observed across prefrontal and temporal regions, with widespread high-intensity signals (red-yellow hues). In contrast, the CID group exhibits markedly reduced activation, limited to sparse clusters (blue-green hues), particularly in the left mPFC and bilateral DLPFC. The color bar indicates activation intensity (ΔHbO₂), with warmer colors representing higher activation.