Table 3 Significantly up- and down-regulated oral metabolites that were reported to play roles in Candida growth, pathogenicity, and host interaction, or modulation of host immune responses.
Oral metabolites | OT vs. C | AT vs. C | OT vs. AT |
|---|---|---|---|
Expression (fold change, p-value) | Expression (fold change, p-value) | Expression (fold change, p-value) | |
Sphingolipids | |||
C17 sphinganine | Up (6.15, 2.71E-02) | Up (2.75, 2.71E-02) | Up (2.24, 2.71E-02) |
Phytosphingosine | Down (-7.32, 1.72E-03) | Down (-122.53, 1.72E-03) | Up (16.737, 1.72E-03) |
CerP(d18:1/20:0) | Down (-346.02, 5.25E-12) | Down (-56.178, 5.25E-12) | Down (-6.159, 5.25E-12) |
MIPC(t18:0/18:0(2OH)) | Down (-250.90, 6.15E-11) | Down (-72.370, 6.15E-11) | Down (-3.467, 6.15E-11) |
Amino acids | |||
D-proline | Up (4.50, 4.58E-03) | Up (2.95, 4.58E-03) | Up (2.15, 4.58E-03) |
L-leucine | Up (1.660, 4.56E-03) | Up (34.10, 4.56E-03) | Down (-20.537, 4.56E-03) |
L-valine | Up (2.42, 4.17E-13) | Down (-3.99, 4.17E-13) | Up (21.33, 4.17E-13) |
Glycerolipids | |||
Monoacylglycerol (MG) (MG(0:0/18:0/0:0)) | Up (7.211, 2.08E-02) | Up (8.161, 2.08E-02) | Down (-7.215, 2.08E-02) |
Triacylglycerol (TG) [TG(17:2(9Z,12Z)/22:2(13Z,16Z)/22:5(7Z,10Z,13Z,16Z,19Z))[iso6]] | Down (-13.64, 2.26E-23) | Down (-24.84, 2.26E-23) | Down (-513.4, 2.26E-23) |
Polyamine | |||
Spermine | Up (2.37, 1.84E-03) | Up (34.87, 1.84E-03) | Down (-14.72, 1.84E-03) |
Spermidine | Down (-1.632, 3.50E-08) | Up (87.21, 3.50E-08) | Down (-142.37, 3.50E-08) |
Glycerophospholipids | |||
Phosphoethanolamine (PE) [PE(17:2(9Z,12Z)/22:6 (4Z,7Z,10Z,13Z,16Z,19Z)] | Up (4.358, 1.17E-06) | Up (11.184, 1.17E-06) | Down (-2.566, 1.17E-06) |
Phosphatidylglycerol (PG) [PG(20:5(5Z,8Z,11Z,14Z,17Z)/0:0) | Down (-5343.6, 1.62E-32) | Up (4.591, 1.62E-32) | Down (-3909.2, 1.62E-32) |
Phosphatidylinositol (PI) [PI(12:0/12:0)] | Down (-233.68, 2.82E-09) | Down (-49.78, 2.82E-09) | Down (-4.694, 2.82E-09) |
Phosphatidylserine (PS) [PS(P-20:0/17:1(9Z))] | Down (-921.3, 6.11E-20) | Down (-114.10, 6.11E-20) | Down (-8.075, 6.11E-20) |
