Table 5 Binary logistic regression analysis of the relationship between alcohol related-SNPs and age-related hearing loss in women.

From: Relationship between age-related hearing loss and alcohol consumption in a Japanese population

Women (N = 6,681)

Pure tone average

4000 Hz

 

N (%)

Alcohol consumption (%)

Normal cases

N (%)

Hearing loss cases

N (%)

Multivariable-adjusted

Interaction analysis

Normal cases

N (%)

Hearing loss cases

N (%)

Multivariable-adjusted

Interaction analysis

Odds ratio (95% CI)

P value

β

Odds ratio (95% CI)

P value

FDR-adjusted

P value

Odds ratio (95% CI)

P value

β

Odds ratio (95% CI)

P value

FDR-adjusted

P value

rs671 (ALDH2)

 G/G

4270 (63.9)

542 (12.7)

2603 (63.5)

1667 (64.6)

1.00

–

–

–

–

–

2296 (63.7)

1974 (64.2)

1.00

–

–

–

–

–

 G/A

2149 (32.2)

59 (2.7)

1346 (32.8)

803 (31.1)

0.89 (0.79–1.01)

0.061

– 0.007

0.993 (0.976–1.009)

0.413

0.413

1171 (32.5)

978 (31.8)

0.94 (0.84–1.05)

0.268

– 0.002

0.998 (0.983–1.012)

0.835

0.835

 A/A

262 (3.9)

0 (0)

152 (3.7)

110 (4.3)

1.10 (0.83–1.45)

0.496

0.533

1.704 (1.028–3.195)

0.075

0.150

139 (3.9)

123(4.0)

0.99 (0.75–1.29)

0.922

0.415

1.514 (0.970–2.817)

0.154

0.307

rs79463616 (ALDH2)

 G/G

4876 (73.0)

405 (8.3)

2997 (73.1)

1879 (72.8)

1.00

–

–

–

–

–

2641 (73.2)

2235 (72.7)

1.00

–

–

–

–

–

 G/A

1646 (24.6)

175 (10.6)

1005 (24.5)

641 (24.8)

1.03 (0.91–1.16)

0.644

0.019

1.019 (1.008–1.029)

 < 0.001

0.001

871 (24.2)

775 (25.2)

1.07 (0.95–1.20)

0.287

0.011

1.011 (1.001–1.021)

0.024

0.047

 A/A

159 (2.4)

21 (13.2)

99 (2.4)

60 (2.3)

0.89 (0.63–1.28)

0.552

– 0.010

0.990 (0.958–1.016)

0.480

0.480

94 (2.6)

65 (2.1)

0.76(0.53–1.06)

0.108

– 0.026

0.974 (0.939–1.002)

0.106

0.106

rs1260326 (GCKR)

 T/T

2172 (32.5)

167 (7.7)

1340 (32.7)

832 (32.2)

1.00

–

–

–

–

–

1160 (32.2)

1012 (32.9)

1.00

–

–

–

–

–

 T/C

3178 (47.6)

292 (9.2)

1947 (47.5)

1231 (47.7)

1.03 (0.92–1.17)

0.597

– 0.002

0.998 (0.987–1.009)

0.768

0.768

1712 (47.5)

1466 (47.7)

0.99 (0.88–1.11)

0.873

– 0.013

0.987 (0.976–1.018)

0.938

0.938

 C/C

1331 (19.9)

142 (10.7)

814 (19.8)

517 (20.0)

1.05 (0.91–1.23)

0.497

– 0.003

0.997 (0.983–1.010)

0.643

0.768

734 (20.4)

597 (19.4)

0.94 (0.82–1.09)

0.441

– 0.011

0.989 (0.976–1.020)

0.698

0.775

rs28712821 (KLB)

 G/G

2301 (34.4)

188 (8.2)

1441 (35.1)

860 (33.3)

1.00

–

–

–

–

–

1274 (35.3)

1027 (33.4)

1.00

–

–

–

–

–

 G/A

3235 (48.4)

311 (9.6)

1963 (47.9

1272 (49.3)

1.10 (0.97–1.24)

0.127

0.010

1.010 (0.999–1.020)

0.077

0.153

1726 (47.9)

1509 (49.1)

1.10 (0.98–1.23)

0.113

0.006

1.006 (0.996–1.016)

0.215

0.429

 A/A

1145 (17.1)

102 (8.9)

697 (17.0)

448 (17.4)

1.07 (0.91–1.25)

0.421

– 0.006

0.994 (0.978–1.008)

0.435

0.435

606 (16.8)

539 (17.5)

1.09 (0.94–1.27)

0.251

– 0.004

0.996 (0.981–1.009)

0.533

0.533

rs1229984 (ADH1B)

 T/T

3847 (57.6)

328 (8.5)

2350 (57.3)

1497 (58.0)

1.00

–

–

–

–

–

2078 (57.6)

1769 (57.5)

1.00

–

–

–

–

–

 T/C

2438 (36.5)

215 (8.8)

1509 (36.8)

929 (36.0)

0.96 (0.86–1.08)

0.280

0.008

1.008 (0.997–1.018)

0.143

0.286

1317 (36.5)

1121 (36.5)

1.00 (0.90–1.11)

0.992

0.001

1.001 (0.991–1.011)

0.768

0.768

 C/C

396 (5.9)

58 (14.6)

242 (5.9)

154 (6.0)

0.93 (0.74–1.17)

0.547

– 0.009

0.991 (0.973–1.008)

0.328

0.328

211 (5.9)

185 (6.0)

0.97 (0.78–1.21)

0.783

0.003

1.003 (0.987–1.018)

0.693

0.768

rs2228093 (ALDH1B1)

 C/C

2965 (44.4)

282 (9.5)

1834 (44.7)

1131 (43.8)

1.00

–

–

–

–

–

1626 (45.1)

1339 (43.5)

1.00

–

–

–

–

–

 C/T

2962 (44.3)

257 (8.7)

1811 (44.2)

1151 (44.6)

1.04 (0.93–1.17)

0.488

0.004

1.004 (0.994–1.014)

0.385

0.518

1573 (43.6)

1389 (45.2)

1.08 (0.97–1.21)

0.142

0.004

1.004 (0.994–1.013)

0.393

0.393

 T/T

754 (11.3)

62 (8.2)

456 (11.1)

298 (11.6)

0.99 (0.83–1.18)

0.880

– 0.006

0.994 (0.977–1.010)

0.518

0.518

407 (11.3)

347 (11.3)

0.97 (0.82–1.16)

0.767

–0 .009

0.991 (0.975–1.006)

0.280

0.393

rs8187929 (ALDH1A1)

 T/T

6222 (93.1)

567 (9.1)

3819 (93.1)

2403 (93.1)

1.00

–

–

–

–

–

3354 (93.0)

2868 (93.3)

1.00

–

–

–

–

–

 T/A + A/A

459 (6.8)

34 (7.4)

282 (6.9)

177 (6.8)

1.03 (0.83–1.26)

0.812

– 0.002

0.997 (0.977–1.017)

0.819

0.819

252 (7.0)

207 (6.7)

0.98 (0.80–1.19)

0.808

–0.049

0.952 (0.976–1.014)

0.492

0.805

rs73550818 (GOT2)

 C/C

1699 (25.4)

139 (8.2)

1044 (25.5)

655 (25.4)

1.00

–

–

–

–

–

918 (25.5)

781 (25.4)

1.00

–

–

–

–

–

 C/A

3328 (49.8)

305 (9.2)

2027 (49.4)

1301 (50.4)

1.00 (0.88–1.14)

0.942

0.001

1.001 (0.989–1.012)

0.861

0.861

1789 (49.6)

1539 (50.0)

0.99 (0.88–1.13)

0.932

0.004

1.004 (0.992–1.015)

0.511

0.511

 A/A

1654 (24.8)

157 (9.5)

1031 (25.1)

623 (24.1)

0.92 (0.79–1.07)

0.299

– 0.002

0.998 (0.983–1.011)

0.726

0.861

899 (24.9)

755 (24.6)

0.96 (0.83–1.11)

0.574

0.008

1.008 (0.995–1.021)

0.208

0.416

  1. Alcohol consumption (%); men (≥ 40 g), women (≥ 20 g).
  2. The multivariable-adjusted model was adjusted for age, history of cardiovascular disease, noisy occupation, family history of hearing loss, educational history, number of teeth, smoking status, hypertension, diabetes, alcohol consumption, and cohort type.
  3. In the interaction analysis, a statistical interaction between alcohol consumption and each SNP was included in the binary logistic regression model.
  4. SNPs, single nucleotide polymorphisms; N, number; β, the regression coefficient; CI, confidence interval; FDR, false discovery rate;
  5. ALDH, acetaldehyde dehydrogenase; GCKR, glucokinase regulatory protein; KLB, klotho beta; ADH, alcohol dehydrogenase;
  6. GOT2, glutamic-oxaloacetic transaminase.
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