Fig. 1 | Scientific Reports

Fig. 1

From: P4HA1 facilitates SPP1+ tumor-associated macrophages by activating the hypoxia pathway in head and neck squamous cell carcinoma

Fig. 1

The abundance of SPP1 + macrophages is negatively associated with patient prognosis in HNSCC. (A) UMAP visualization showed 172,569 cells from 52 HNSCC patients, categorized into 10 distinct cell types. (B) Heatmap exhibited the expression levels of marker genes for the 10 cell types. (C) UMAP plot showing 8 subtypes of macrophages. (D) The marker genes of macrophage subtypes are presented in a contour density plot. (E) The immune infiltration of the 8 macrophage subtypes in the TCGA-HNSCC cohort. (F) The box plot shows the infiltration ratios of eight macrophage subtypes in HNSCC and adjacent normal tissues. (G) Univariate Cox regression analysis of eight macrophage subtypes. (H) Kaplan-Meier survival analysis of high and low SPP1+ macrophage infiltration groups. *,p < 0.05,**, p < 0.01; ***.

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