Fig. 3

Geometric Mean Ratio (GMR) comparing humoral immunogenicity (Anti-S IgG, 3a; NT50 against ancestral, 3b; NT50 against Omicron XBB.1.5, 3c) after boosting of bivalent mRNA COVID-19 vaccine between mRNA-based vs. Ad26.COV2.S vector-based or between mRNA-based vs. ChAdOx1 vector-based vaccine at dose 3, per-protocol analysis. A GMR value of less than 1.0 indicates that the previously received mRNA platform vaccine has a better response to the bivalent booster than the previously received vector-based vaccine.