Fig. 1
Pancreatic histopathology and serum injury markers in SAP-IBI mice. A: HE-stained pancreatic sections at 24-hour intervals (×200), SO group (n = 10), SAP-IBI group (n = 5), SAP + AAV-NC group (n = 6), SAP + AAV-AIM2 shRNA group (n = 8), SAP + AAV-AIM2 OE group (n = 5). B: Quantitative analysis of pancreatic histopathological scores. C: Quantitative analysis of serum amylase. D: Quantitative analysis of serum lipase. E: Quantitative analysis of serum PLA2. SO group: Sham-operation control group; SAP-IBI group: Severe acute pancreatitis-induced brain injury model group; SAP + AAV-NC group: Mice administered 3 × 10^11 v.g. of control AAV via tail vein and subjected to SAP-IBI modeling after a 21-day interval; SAP + AAV-AIM2 shRNA group: Mice administered 3 × 10^11 v.g. of AIM2-targeting shRNA AAV via tail vein and subjected to SAP-IBI modeling after a 21-day interval; SAP + AAV-AIM2 OE group: Mice administered 3 × 10^11 v.g. of AIM2-overexpressing AAV via tail vein and subjected to SAP-IBI modeling after a 21-day interval. Statistical annotations: * P < 0.05 compared with the SO group; # P < 0.05 compared with the SAP-IBI group.
