Table 2 Multivariable cox regression to assess the association of fibrinogen with mortality

From: U shaped association between fibrinogen and one year mortality in women undergoing coronary artery bypass grafting

 

Model 1

Model 2

Model 3

Model 4

Model 5

HR (95% CI)

P value

HR (95% CI)

P value

HR (95%CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

One-year mortality

continuous variable

1.02 (1 ~ 1.05)

0.095

1.03 (1 ~ 1.06)

0.028

1.02 (1 ~ 1.05)

0.037

1.02 (0.98 ~ 1.06)

0.308

1.01 (0.97 ~ 1.05)

0.563

Categorical variable

Q1(≤ 155)

2.72 (1.13 ~ 6.56)

0.026

2.44 (1.01 ~ 5.93)

0.049

2.33 (0.95 ~ 5.69)

0.064

2.2 (0.86 ~ 5.62)

0.098

2.91 (1.14 ~ 7.46)

0.026

Q2(155–178)

1.02 (0.36 ~ 2.92)

0.963

0.98 (0.34 ~ 2.8)

0.969

0.89 (0.31 ~ 2.57)

0.828

0.79 (0.26 ~ 2.42)

0.681

0.98 (0.31 ~ 3.04)

0.969

Q3(178–201)

1.75 (0.68 ~ 4.52)

0.246

1.71 (0.66 ~ 4.42)

0.268

1.68 (0.65 ~ 4.37)

0.285

2.21 (0.83 ~ 5.9)

0.113

3.37 (1.22 ~ 9.33)

0.02

Q4(201–230)

1 (Ref)

1 (Ref)

1 (Ref)

1 (Ref)

1 (Ref)

Q5(230–267)

0.89 (0.3 ~ 2.66)

0.841

0.92 (0.31 ~ 2.73)

0.873

0.92 (0.31 ~ 2.74)

0.876

1.15 (0.38 ~ 3.48)

0.809

1.45 (0.46 ~ 4.59)

0.524

Q6(>267)

2.71 (1.13 ~ 6.49)

0.025

2.96 (1.23 ~ 7.14)

0.015

2.93 (1.22 ~ 7.06)

0.016

3.68 (1.46 ~ 9.29)

0.006

4.3 (1.66 ~ 11.13)

0.003

P for tread

0.832

 

0.797

 

0.644

 

0.351

 

0.597

  1. Model 1: No adjustment.
  2. Model 2: Adjusted for demographic variables (age, BMI).
  3. Model 3: Adjusted for demographic variables, Basic vital signs(heart rate, ABPS, ABPD, Temperature).
  4. Model 4: Adjusted for demographic variables, Basic vital signs, Blood biochemical indicators (WBC, RBC, platelet count, sodium, potassium, calcium total, chloride, glucose, anion gap, lactate, urea nitrogen, creatinine).
  5. Model 5: Adjusted for demographic variables, Basic vital signs, Blood biochemical indicators, SOFA, APS Ⅲ, SAPSⅡ, GCS, CHARLSON.
  6. Abbreviations: the unit of fibrinogen is mmol/L, change per 10, BMI: body mass index; ABPS: Arterial systolic pressure; ABPD: Arterial diastolic pressure; WBC: white blood cell count; RBC: red blood cell count; sofa: Sequential Organ Failure Assessment; APS Ⅲ: Acute Physiology and Chronic Health Evaluation Ⅲ; SAPSⅡ: simplified acute physiology score Ⅱ; GCS: Glasgow Coma Scale; CHARLSON: Charlson comorbidity index, AKI: acute kidney injury; CRRT: Continuous Renal Replacement Therapy; CI: confidence interval; HR: hazard ratio; Ref: reference.
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