Fig. 6

Target gene networks of differentially expressed miRNAs. (a) Network interaction diagram of target genes for the nine DEmiRNAs. The number of edges connected to a target gene corresponds to its Maximal Clique Centrality (MCC) value, with more edges indicating a higher MCC rank. Nodes are color-coded from red (highest rank) to yellow (lowest rank). (b) The top seven key target genes of miRNAs exhibiting the “upregulated in Model group + downregulated in USMB group” expression pattern. Nodes are colored from orange to yellow, with color intensity increasing with the prediction score. GSK3β achieved the highest score. (c) Regulatory network of the top four target genes of rno-miR-26b-5p.