Fig. 1

OVCAR-8 and OVCAR-3 Pt-resistant (R) and sensitive (S) HGSOC cells were treated with S2 0% (A) 1% S2 and 3% S2 (B, D) and 1 % S2 and 3% +20 \({\upmu }\)g/ml Yth53.1 (C, E). HGSOC cells were tracked from PE Annexin V and 7-AAD negative (viable, or no measurable apoptosis), to PE Annexin V positive and 7-AAD negative (early apoptosis, membrane integrity is present) and finally to PE Annexin V and 7-AAD positive (end stage apoptosis and death).