Fig. 4 | Scientific Reports

Fig. 4

From: Paeoniflorin inhibits angiogenesis in multiple myeloma by decreasing the MEF2A level to downregulate the expression of lncRNA MALAT1 within exosomes

Fig. 4

PF inhibit angiogenesis by decrease the MALAT1 level of exosomes. (A) The MALAT1 level was assessed using PCR in different dosage groups treated with PF, the medium-dose PF treated group was selected for further investigation based on the level of MALAT1. (B) The cell viability assays were conducted on HUVEC cells, following co-culture with exosomes which derived from U266 cells after treated with or without a medium dose of PF. (C, D) Tube formation assays were performed on HUVEC cells. (E, F) VEGFA level was tested by PCR or ELISA. Three independent experiments were performed. *P < 0.05, **P < 0.01.

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