Table 3 The effect size of CUN-BAE on MASLD in prespecified and exploratory subgroups in each subgroup.

From: CUN‑BAE predicts risk of metabolic dysfunction–associated steatotic liver disease: A prospective cohort study in non‑obese Chinese adults

CUN-BAE z-score

N

HR (95%CI) P-value

P interaction

Age, years

  

0.5852

< 30

3548

1.45 (1.31, 1.61) < 0.001

 

≥ 30, < 45

6480

1.35 (1.26, 1.45) < 0.001

 

≥ 45, < 60

3777

1.29 (1.19, 1.41) < 0.001

 

≥ 60

2368

1.21 (1.07, 1.36) 0.002

 

SBP, mmHg

  

0.6367

< 140

14,090

1.39 (1.32, 1.45) < 0.001

 

≥ 140

2083

1.22 (1.11, 1.34) < 0.001

 

DBP, mmHg

  

0.0340

< 90

15,024

1.37 (1.31, 1.44) < 0.001

 

≥ 90

1149

1.17 (1.05, 1.31) 0.005

 

ALT, U/L

  

0.0790

< 40

15,438

1.38 (1.32, 1.45) < 0.001

 

≥ 40

735

1.19 (1.05, 1.35) 0.005

 

AST, U/L

  

0.1332

< 40

15,804

1.34 (1.28, 1.40) < 0.001

 

≥ 40

369

1.37 (1.12, 1.67) 0.002

 

UA, mmol/L

  

0.0007

< 360

13,329

1.45 (1.37, 1.53) < 0.001

 

≥ 360

2843

1.23 (1.14, 1.32) < 0.001

 

CR, µmo/L

  

0.7752

< 104

14,759

1.35 (1.29, 1.41) < 0.001

 

≥ 104

1413

1.31 (1.17, 1.47) < 0.001

 

TG, mmol/L

  

< 0.0001

< 1.7

13,090

1.48 (1.39, 1.57) < 0.001

 

≥ 1.7

3083

1.18 (1.11, 1.26) < 0.001

 

HDL-C, mmol/L

  

0.0991

< 1.03

1647

1.24 (1.12, 1.37) < 0.001

 

≥ 1.03

14,526

1.38 (1.32, 1.45) < 0.001

 

TC, mmol/L

  

0.7185

< 5.2

12,563

1.34 (1.28, 1.41) < 0.001

 

≥ 5.2

3610

1.28 (1.18, 1.38) < 0.001

 

FPG, mmol/L

  

0.7257

< 6.1

15,219

1.36 (1.30, 1.43) < 0.001

 

≥ 6.1

953

1.26 (1.10, 1.43) < 0.001

 
  1. The subgroup analyses examining the association between CUA-BAE and MASLD were adjusted for the following covariates: ALT; AST; TP; ALB; GLB; BUN; CR; UA; TC; TG; HDL; LDL-C; FPG; SBP; DBP, excluding the stratified variables.
  2. Abbreviations: ALB, Albumin; ALP, Alkaline phosphatase; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; BUN, Blood urea nitrogen; Cr, Creatinine; CUN-BAE, Clínica Universidad de Navarra-Body Adiposity Estimator; DBP, Diastolic blood pressure; FPG, Fasting plasma glucose; GGT, Gamma-glutamyl transferase; GLB, Globulin; HDL-C, High-density lipoprotein cholesterol; LDL-C, Low-density lipoprotein cholesterol; MASLD, Metabolic Dysfunction-Associated Steatotic Liver Disease; SBP, Systolic blood pressure; TB, Total bilirubin; TC, Total cholesterol; TG, Triglyceride; TP, Total Protein; TYG, Triglyceride-Glucose index; UA, Uric acid.
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