Fig. 1
From: Transcriptome analysis of orbital tissue in thyroid eye disease uncovers key pathogenic mediators
Identification and functional characterization of differentially expressed genes in TED. a Wayne diagram shows the gene expression level of orbital connective tissue in TED and controls. The blue part indicates that there are 164 genes specifically expressed in TED, the orange part indicates that 399 genes are specifically expressed in controls, and the dark overlap indicates that there are 11,399 genes expressed between the two groups. b Heatmap from the hierarchical clustering analysis showed the differential expressed mRNAs between the two groups. The color scale on the top illustrates the relative expression level of mRNAs across all samples: red denotes mRNA expression greater than the average value, and blue denotes mRNA expression lesser than the average value. A: TED group, B:control group. c Volcano plots of all detected mRNAs in the TED and Control groups. The red dots represent significantly upregulated genes (log2 fold change > 1 and adjusted P < 0.05); the blue dots represent significantly downregulated genes (log2 fold change < − 1 and adjusted P < 0.05).
