Fig. 3
From: Gut–ovary axis and multiomic insights into PCOS in a DHEA-induced rat model
General characteristics of differential metabolites in stool, cecum, serum and ovarian metabolomes in the PCOS and control groups. (A–D) Volcano plots of DEMs in the stool, serum, cecum, and ovary metabolomes. The blue and red dots indicate upregulated and downregulated DEMs in these four types of samples, respectively. (Control, n = 9; PCOS, n = 10). (E–H) Heatmap of DEMs (VIP > 1, p < 0.05) between both groups in the stool, serum, cecum, and ovary metabolomes. The rows represents the metabolites, and the columns indicate the samples of each group. The color represents the relative abundance of the DEMs in samples. The VIP bar graph of DEMs is listed on the right. The size of the VIP value represents the contribution value of the metabolite to the difference between the groups. *p < 0.05; **p < 0.01; ***p < 0.001.
