Fig. 8
From: Gut–ovary axis and multiomic insights into PCOS in a DHEA-induced rat model
DHEA treatment induce impaired intestinal integrity and disturbed ovarian steroid hormone metabolism in recipient rat’s ovary (*p < 0.05; **p < 0.01; ***p < 0.001). (A) The expression levels of mRNAs involved in ovarian steroid hormone metabolism (HSD3B2, CYP4B1, CYP17A, STAR) determined by real time PCR. (B) The expression levels of intercellular junction mRNA s (CLDN2, CLDN3, Occludin) in colonic tissues. (C) The expression levels of enzymes of ovarian steroid hormone metabolism (Cyp4f17, Cyp4b1, and 3B-HSD) determined by WB.
