Table 2 Subgroup analysis of OS and DFS of the pooled HR.
No. of research | No. of patients | Pooled HR (95% CI) | Heterogeneity | |||
|---|---|---|---|---|---|---|
Fixed | Random | I2(%) | P-value | |||
Overall survival (OS) | 26 | 4657 | 1.72(1.57–1.88) | 1.92(1.65–2.23) | 52.3 | 0.001 |
Cancer type | ||||||
Digestive system | 20 | 3871 | 1.66(1.51–1.83) | 1.89(1.58–2.26) | 59.6 | 0.001 |
Non-digestive system | 6 | 786 | 2.13(1.67–2.72) | 2.13(1.67–2.72) | 0 | 0.849 |
Sample size | ||||||
≥ 120 | 19 | 4135 | 1.64(1.49–1.80) | 1.72(1.51–1.95) | 30.2 | 0.104 |
<120 | 7 | 522 | 3.09(2.22–4.29) | 3.02(1.75–5.19) | 55.1 | 0.038 |
HR estimation method | ||||||
Directly | 17 | 3312 | 1.68(1.52–1.86) | 1.79(1.55–2.07) | 31.8 | 0.102 |
Indirectly | 9 | 1345 | 1.86(1.54–2.26) | 2.17(1.44–3.28) | 71.5 | 0.001 |
Region | ||||||
Asian | 23 | 4392 | 1.70(1.55–1.86) | 1.86(1.61–2.17) | 52.6 | 0.002 |
Non-asian | 3 | 265 | 4.49(2.02–9.96) | 4.49(2.02–9.96) | 0 | 0.861 |
Disease-free-survival (DFS) | 12 | 1806 | 1.55(1.34–1.79) | 1.81(1.39–2.36) | 65.1 | 0.001 |
Cancer type | ||||||
Digestive system | 11 | 1744 | 1.50(1.29–1.74) | 1.69(1.31–2.17) | 60.2 | 0.005 |
Non-digestive system | 1 | 62 | 4.57(1.95–10.71) | 4.57(1.95–10.71) | - | - |
Sample size | ||||||
≥ 120 | 7 | 1415 | 1.41(1.20–1.66) | 1.50(1.20–1.89) | 45.3 | 0.089 |
<120 | 5 | 391 | 2.34(1.66–3.29) | 2.52(1.32–4.83) | 71.0 | 0.008 |
HR estimation method | ||||||
Directly | 7 | 1011 | 1.85(1.51–2.27) | 2.08(1.52–2.85) | 50.1 | 0.061 |
Indirectly | 5 | 795 | 1.29(1.05–1.59) | 1.81(1.39–2.36) | 70.7 | 0.008 |
Region | ||||||
Asian | 9 | 1541 | 1.42(1.22–1.65) | 1.52(1.200–1.91) | 50.1 | 0.042 |
Non-asian | 3 | 265 | 3.36(2.13–5.30) | 3.54(1.97–6.36) | 36.7 | 0.206 |
