Fig. 5 | Scientific Reports

Fig. 5

From: Chromatin accessibility of circulating CD8⁺ T cells differentiates disease severity in IgA nephropathy

Fig. 5

Prediction of chromatin openness using composite biomarker. a Schematic of weighted openness score calculation. For each biomarker, normalized values above or below the cut-off were scored as 1 or 0, respectively. Weighted sums were calculated across markers. b, c Openness scores for early-stage (blue) and late-stage (red) groups are shown as dot plots (left), with mean ± SEM for each group (early: n = 11, late: n = 6). Statistical significance was determined by Student’s t-test. ROC curves (middle) and waterfall plots (right) visualize predictive performance and individual openness scores.

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