Table 1 Baseline levels of characteristics according to eGDR quartiles.

From: Low estimated glucose disposal rate (eGDR) predicts decreased all-cause mortality in critically ill patients with cardiorenal syndrome (CRS): analysis of the MIMIC-IV database

Variable

Total(n = 2398)

Quartiles of eGDR

P-value

Q1(n = 600)

Q2(n = 599)

Q3(n = 600)

Q4(n = 599)

Demographic

      

eGDR

5.5(3.9,6.6)

2.5(1.2,3.3)

4.8(4.4,5.2)

6.1(5.8,6.3)

7.5(7.1,8.3)

 < 0.001

Age, years

71.0(61.0,79.0)

65.0(57.0,73.0)

71.0(62.0,78.0)

74.0(65.0,81.0)

73.0(62.0,81.0)

 < 0.001

Male, n (%)

1468(61.2)

334(55.7)

398(66.4)

380(63.3)

356(59.4)

0.001

BMI, Kg/m2

28.8(24.7,33.9)

38.5(34.1,43.9)

30.9(28.8,33.2)

26.8(25.1,28.5)

23.1(21.0,25.1)

 < 0.001

Length of ICU stays, days

3.1(1.5,6.2)

3.1(1.6,6.3)

2.9(1.3,5.7)

3.0(1.4,5.7)

3.3(1.8,6.9)

0.112

Laboratory tests

      

RBC, m/uL

3.3(2.8,3.9)

3.5(2.9,4.1)

3.3(2.8,3.8)

3.3(2.7,3.8)

3.2(2.7,3.9)

 < 0.001

WBC, K/uL

11.2(8.1,15.5)

11.5(8.5,15.6)

10.9(8.0,14.8)

10.5(7.8,14.7)

11.9(7.9,17.0)

0.005

PLT, K/uL

182.0(135.0,245.0)

205.5(157.0,260.5)

176.0(133.0,238.0)

172.0(131.0,235.0)

173.0(125.0,240.0)

 < 0.001

Glucose, mg/dL

136.5(107.0,188.0)

155.0(118.0,229.7)

140.0(108.0,191.0)

130.0(105.0,174.0)

126.0(103.0,167.0)

 < 0.001

HbA1c, %

6.2(5.7,7.2)

7.5(6.4,9.5)

6.5(6.0,7.5)

6.0(5.6,6.6)

5.7(5.3,6.1)

 < 0.001

AST, IU/L

43.0(21.0,162.0)

42.0(20.0,161.5)

38.0(20.0,123.4)

46.0(21.0,211.7)

48.0(23.0,174.1)

0.031

ALT, IU/L

27.0(12.0,107.2)

28.0(13.0,106.0)

26.0(11.0,79.8)

26.0(12.0,115.7)

28.0(12.0,127.0)

0.154

PT, sec

15.1(13.1,18.4)

14.4(12.8,17.6)

15.4(13.1,18.4)

15.4(13.3,18.7)

15.3(13.1,18.8)

0.003

PTT, sec

33.4(28.6,52.8)

32.5(27.8,52.9)

34.0(28.7,52.7)

33.3(28.9,52.5)

33.8(28.9,53.1)

0.228

INR

1.3(1.1,1.7)

1.3(1.1,1.7)

1.3(1.1,1.64)

1.3(1.1,1.60)

1.3(1.14,1.7)

0.438

CK-MB, IU/L

5.7(2.0,23.3)

5.0(2.0,21.0)

5.0(2.0,17.0)

5.2(2.0,24.2)

7.0(3.0,32.3)

 < 0.001

TnT, ng/ml

0.24(0.03,1.32)

0.19(0.03,1.24)

0.23(0.02,1.08)

0.21(0.02,1.42)

0.38(0.05,1.57)

0.002

SCR

1.1(0.9,1.6)

1.1(0.9,1.7)

1.1(0.9,1.6)

1.1(0.9,1.6)

1.0(0.8,1.5)

 < 0.001

ALB

3.8(3.3,4.1)

3.7(3.3,4.1)

3.8(3.4,4.2)

3.8(3.4,4.2)

3.7(3.2,4.1)

 < 0.001

SOFA

4.0(2.1,5.4)

4.0(2.1,5.0)

4.0(2.0,5.7)

4.0(2.6,5.6)

4.0(2.0,6.0)

0.621

APSIII

52.0(41.0,69.0)

54.0(43.0,70.5)

50.0(39.0,67.5)

50.0(40.0,66.0)

54.0(42.0,70.5)

0.012

SAPSII

41.0(34.0,50.0)

40.0(32.5,49.0)

41.0(33.0,50.0)

42.0(34.5,50.0)

41.0(34.5,50.0)

0.032

Comorbidities

      

Anemia, n (%)

512(21.4)

129(21.5)

131(21.9)

118(19.7)

134(22.4)

0.685

AF, n (%)

1192(49.7)

244(40.7)

319(53.3)

315(52.5)

314(52.4)

 < 0.001

CAD, n (%)

1390(58.0)

332(55.3)

373(62.3)

373(62.2)

312(52.1)

 < 0.001

MI, n (%)

743(31.0)

164(27.3)

191(31.9)

197(32.8)

191(31.9)

0.161

DM, n (%)

796(33.2)

286(47.7)

237(39.6)

183(30.5)

90(15.0)

 < 0.001

Hypercholesteremia, n (%)

186(7.8)

54(9.0)

47(7.8)

50(8.3)

35(5.8)

0.199

Hypertension, n (%)

2230(93.0)

591(98.5)

592(98.8)

592(98.7)

455(76.0)

 < 0.001

TIA, n (%)

236(9.8)

54(9.0)

51(8.5)

69(11.5)

62(10.4)

0.295

PVD, n (%)

530(22.1)

103(17.2)

142(23.7)

154(25.7)

131(21.9)

0.003

Dementia, n (%)

49(2.0)

12(2.0)

13(2.2)

14(2.3)

10(1.7)

0.867

CVD, n (%)

363(15.1)

84(14.0)

90(15.0)

90(15.0)

99(16.5)

0.678

CRRT, n (%)

237(9.9)

72(12.0)

47(7.8)

59(9.8)

59(9.8)

0.121

Ventilation, n (%)

2188(91.2)

551(91.8)

547(91.3)

545(90.8)

545(91.0)

0.931

Outcomes

      

30-day mortality

344(14.3)

67(11.2)

67(11.2)

95(15.8)

115(19.2)

 < 0.001

90-day mortality

503(21.0)

96(16.0)

103(17.2)

135(22.5)

169(28.2)

 < 0.001

180-day mortality

603(25.1)

116(19.3)

125(20.9)

165(27.5)

197(32.9)

 < 0.001

360-day mortality

753(31.4)

156(26.0)

163(27.2)

200(33.3)

234(39.1)

 < 0.001

  1. eGDR estimated glucose disposal rate; BMI body mass index; RBC red blood cell; WBC white blood cell; PLT platelet; TC total cholesterol; HbA1C glycosylated hemoglobin; ALT alanine transaminase; AST aspartate transaminase; PT prothrombin time; ALB albumin; SCR serum creatinine; PTT partial thromboplastin time; INR international normalized ratio; CK-MB creatine kinase MB isoenzyme; TnT Troponin T; CAD coronary artery disease; AF atrial fibrillation; MI myocardial infarction; DM diabetes; TIA transient ischemic attack; PVD peripheral vascular disease; CVD cerebrovascular disease; CRRT continuous renal replacement therapy;
  2. Continuous data are presented as median (interquartile range). Categorical variables are presented as numbers (proportions).
  3. P values in bold meant significantly different (P < 0.05).
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