Fig. 8

Top 5 downregulated and upregulated Gene Ontology (GO) biological processes identified by over-representation analysis (ORA) for each diagnosis compared to the rest of the cohort: (a) breast carcinoma, (b) colorectal carcinoma, (c) non-small cell lung carcinoma, (d) melanoma, and (e) renal clear cell carcinoma brain metastases. Cut-off: padj < 0.01, fold enrichment ≥ 1.5. Bars represent statistical significance (± log10(padj)).