Table 1 Comparison of calibration curve parameters for yield of dicentric chromosome aberration in peripheral blood lymphocytes of two healthy donors by using Giemsa or Centromere-FISH staining at 0–5 Gy.

From: Optimized dicentric chromosome dose–response curves with centromere probes improve low-dose radiation biodosimetry

DRC

y = C + αD + βD2

Goodness of fit

Minimum detectable dose

(mGy)

95% CI

(mGy)

C ± SE

α ± SE (p-value)

β ± SE (p-value)

χ2

df

p-value

G2-DRC-1

0.0005 ± 0.0002

0.0236 ± 0.0042

(p = 0.0005, p < 0.05)

0.0500 ± 0.0028

(p = 0.0000, p < 0.05)

10.4400

9

0.3160

89

5–234

G2-DRC-2

0.0012 ± 0.0004

0.0253 ± 0.0034

(p = 0.0000, p < 0.05)

0.0492 ± 0.0029

(p = 0.0000, p < 0.05)

13.1100

9

0.1578

121

16–271

F2-DRC-1

0.0006 ± 0.0004

0.0279 ± 0.0079

(p = 0.0029, p < 0.05)

0.0766 ± 0.0061

(p = 0.0000, p < 0.05)

24.6200

9

0.0034

72

1–192

F2-DRC-2

0.0009 ± 0.0005

0.0278 ± 0.0061

(p = 0.0014, p < 0.05)

0.0744 ± 0.0061

(p = 0.0000, p < 0.05)

30.1800

9

0.0002

90

7–214

  1. * Data were derived from two healthy donors (aged 32–38 years; male).
  2. * All dose–response curves (DRCs) were constructed and coefficient and statistical values were obtained from Dose Estimate ver. 5.2.
  3. * Minimum detectable dose (MDD) and 95% CI were calculated estimated dose by using our fitting curves with Dose Estimate ver. 5.2.
  4. * Dose–response curve conditions were described in Sect. 2.5 of Materials and Methods.
  5. * CI: 95% upper and lower confidence interval of MDD.
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