Table 1 Characteristics of the studies related to TPT acceptance in Chinese children and adolescents.

From: Acceptance of preventive therapy for latent tuberculosis infection in Chinese children and adolescents: a systematic review and meta-analysis

Study

Study design

Region

Study year

Research setting

Preventive therapy criteria

Regimen

Sample size

Initiated TPT

Dong et al.31

Cross-sectional study

Jiangsu Province

2005

Routine screening

TST ≥ 20 mm or strong reaction (blisters, necrosis, lymphangitis)

6H2P2

307

260

Guo et al.32

Cross-sectional study

Jiangsu Province

2018–2021

Routine screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis) or IGRA positive

3HR

397

215

Zhou et al.35

Cross-sectional study

Guangdong Province

2011

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

6 H

187

150

Wu33

Cross-sectional study

Chongqing Municipality

2017–2018

Household contact screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3H2P2

25

20

Wu33

Cross-sectional study

Chongqing Municipality

2017–2018

Household contact screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

6 H

26

19

Shi34

Cross-sectional study

Sichuan Province

2016

Routine screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

31

3

Yu et al.36

Cross-sectional study

Henan Province

2010

Routine screening

TST ≥ 10 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

846

627

Hu et al.37

Cross-sectional study

Henan Province

2017

Routine screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

397

248

Guan et al.38

Cross-sectional study

Shandong Province

Not reported

Routine screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3H2P2

24

16

Jiang et al.39

Cross-sectional study

Shandong Province

Not reported

Routine screening

TST ≥ 20 mm or strong reaction (blisters, necrosis, lymphangitis)

3H2P2

26

16

Pan et al.40

Cross-sectional study

Guangxi Province

2019–2020

Routine screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

90

10

Jia et al.41

Cross-sectional study

Beijing Municipality

2018–2019

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3H2P2

62

39

Weng et al.42

Cross-sectional study

Zhejiang Province

2013–2014

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

23

21

Li et al.43

Cross-sectional study

Henan Province

2018

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3H2P2

143

111

Zheng44

Cross-sectional study

Liaoning Province

2015

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

6 H

64

42

Gong et al.45

Cross-sectional study

Zhejiang Province

2016

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

11

10

Hou et al.46

Cross-sectional study

Guangxi Province

2023

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

100

31

Wang et al.47

Cross-sectional study

Shanxi Province

Not reported

Routine screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

6 H

63

38

Fan et al.48

Cross-sectional study

Chongqing Municipality

2020–2021

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis) or IGRA positive

3HR

44

36

Chen et al.49

Cross-sectional study

Henan and Hunan Province

2018–2020

Household contact screening

IGRA positive

6 H

228

185

Chen et al.49

Cross-sectional study

Henan and Hunan Province

2018–2020

Household contact screening

IGRA positive

3H2P2

273

234

Chen et al.49

Cross-sectional study

Chongqing Municipality

2018–2020

Household contact screening

IGRA positive

6 H

149

120

Chen et al.49

Cross-sectional study

Chongqing Municipality

2018–2020

Household contact screening

IGRA positive

3H2P2

39

25

Li et al.50

Cohort study

Jiangsu Province

2004–2007

Routine screening

TST ≥ 20 mm or strong reaction (blisters, necrosis, lymphangitis)

6 H

195

92

Li et al.51

Cohort study

Beijing Municipality

2016–2019

School outbreak screening

TST ≥ 10 mm or strong reaction (blisters, necrosis, lymphangitis)

3H2P2

91

72

Fang et al.52

Cohort study

Zhejiang Province

2016–2019

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

6 H

30

4

Fang et al.53

Cohort study

Zhejiang Province

2019 − 2010

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

6 H

122

69

Huang54

Cohort study

Guangdong Province

2013–2017

Routine screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

348

151

Zou et al.55

Cohort study

Hunan Province

2020–2021

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

144

130

Hu et al.56

Cohort study

Shanghai Municipality

2018–2020

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3H2P2

12

5

Zhou et al.57

Cohort study

Henan Province

2019–2021

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

136

110

Weng et al.58

Cohort study

Zhejiang Province

2008–2012

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

179

86

Tang et al.59

Cohort study

Anhui Province

2018–2019

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

52

34

Zhang et al.60

Cohort study

Jiangsu Province

2014–2016

School outbreak screening

TST ≥ 10 mm or strong reaction (blisters, necrosis, lymphangitis)

3HR

34

4

Xu et al.61

Cohort study

Zhejiang Province

2018–2020

School outbreak screening

TST ≥ 15 mm or strong reaction (blisters, necrosis, lymphangitis)

3H2P2

31

30

  1. 6 H: Take isoniazid once a day and continue for six months. 3HR: Take isoniazid and rifampicin once a day for three months. 3H2P2: Take isoniazid and rifapentine twice a week for three consecutive months.